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The presence of Corynebacterium in granulomatous mastitis was first reported in 1996. [14] Since then multiple reports have confirmed the presence of this genus in granulomatous mastitis. [15] [16] [17] The most commonly isolated species is Corynebacterium kroppenstedtii. A selective medium for the isolation of this species has been described. [18]
Although no causal relation with breast cancer has been established, there appears to be an increased statistical risk of breast cancer, warranting a long-term surveillance of patients diagnosed with non-puerperal mastitis. [5] Nonpuerperal breast abscesses have a higher rate of recurrence compared to puerperal breast abscesses. [6]
When it occurs in breastfeeding mothers, it is known as puerperal mastitis, lactation mastitis, or lactational mastitis. When it occurs in non breastfeeding women it is known as non-puerperal or non-lactational mastitis. Mastitis can, in rare cases, occur in men. Inflammatory breast cancer has symptoms very similar to mastitis and must be ruled ...
The periareolar glands of Montgomery in the breast are also called Montgomery tubercles or Morgagni tubercles. These periareolar glands are small, papular tissue projections at the edge of the areola (nipple).Obstruction of the Montgomery tubercles may result in an acute inflammation, a clear or light brownish fluid may drain out of the areola (nipple discharge), and an subareolar mass may ...
Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, [1] is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. [2]
Treatment of silicone granulomas and removal of unwanted silicone have historically been very challenging. Anti-inflammatory agents (e.g., oral corticosteroids, allopurinol, colchicine, isotretinoin, cyclosporine, imiquimod, antibiotics) may help treat the granulomatous inflammation, [17] but do not address or remove the underlying source silicone material.
Other names for the condition include chronic cystic mastitis, fibrocystic mastopathy and mammary dysplasia. [27] The condition has also been named after several people (see eponyms below). Since it is a very common disorder, some authors have argued that it should not be termed a disease, [ 28 ] whereas others feel that it meets the criteria ...
On histopathological examination, a biopsy will show leukocytoclastic vasculitis with necrotic changes and granulomatous inflammation (clumps of typically arranged white blood cells) on microscopy. These granulomas are the main reason for the name granulomatosis with polyangiitis, although it is not an essential feature.