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Amiodarone is also safe to use in individuals with cardiomyopathy and atrial fibrillation, to maintain normal sinus rhythm. Amiodarone prolongation of the action potential is uniform over a wide range of heart rates, so this drug does not have reverse use-dependent action. Amiodarone was the first agent described in this class. [4]
Amiodarone has been used both in the treatment of acute life-threatening arrhythmias as well as the long-term suppression of arrhythmias. [13] Amiodarone is commonly used to treat different types of abnormal heart rhythms, such as atrial arrhythmias (supraventricular arrhythmias) and ventricular arrhythmias.
Amiodarone induced thyrotoxicosis (AIT) is a form of hyperthyroidism due to treatment with antiarrhythmic drug, amiodarone. Amiodarone induced thyroid dysfunction more commonly results in hypothyroidism , estimated to occur in 6-32% of patients, whereas hyperthyroidism from amiodarone use is estimated at 1-12%. [ 1 ]
For this reason, drugs with a long half-life (e.g., amiodarone, elimination t 1 / 2 of about 58 days) are usually started with a loading dose to achieve their desired clinical effect more quickly.
Arrhythmias not due to structural heart disease account for 5 to 10% of sudden cardiac arrests. [ 42 ] [ 43 ] [ 44 ] These are frequently caused by genetic disorders . [ 30 ] The genetic mutations often affect specialized proteins known as ion channels that conduct electrically charged particles across the cell membrane , and this group of ...
Amiodarone. Amiodarone works in many ways. It blocks sodium, potassium, and calcium channels, as well as alpha and beta adrenergic receptors. Because of its multiple actions, amiodarone causes QT prolongation but TdP is rarely observed. Dofetilide; Ibutilide
LOS ANGELES (AP) — The two biggest wildfires ravaging the Los Angeles area have burned at least 10,000 homes, buildings and other structures, officials said Thursday as they urged more people to heed evacuation orders after a new blaze ignited and quickly grew.
Further signs that may be seen on physical examination are most commonly a diffusely enlarged (usually symmetric), nontender thyroid, lid lag, excessive lacrimation due to Graves' ophthalmopathy, arrhythmias of the heart, such as sinus tachycardia, atrial fibrillation, and premature ventricular contractions, and hypertension.