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SIRT, when added to first line therapy for patients with metastases of colorectal cancer, was evaluated in the SIRFLOX, [12] FOXFIRE [13] and FOXFIRE Global [14] studies. For primary liver cancer (HCC), two large trials comparing SIRT with standard of care chemotherapy, Sorafenib, have been completed, namely the SARAH [15] and SIRveNIB [16] trials.
Primary liver cancer, also known as hepatocellular carcinoma (HCC), is the most frequent type of liver cancer, accounting for approximately 90% of the primary malignant liver tumours in adults. Liver cancer is the sixth most prevalent malignancy and the third greatest cause of cancer-related deaths worldwide. [5] Every year, around 600,000 ...
SIR-Spheres microspheres are used to treat patients with unresectable liver cancer. These are mostly patients with hepatocellular carcinoma (HCC), metastatic colorectal cancer (mCRC), or metastatic neuroendocrine tumours (mNET). [1] Therapy goals are local disease control, downstaging to resection, bridging to transplantation, and extended ...
Transcatheter arterial chemoembolization (TACE) is a minimally invasive procedure performed in interventional radiology to restrict a tumor's blood supply. Small embolic particles coated with chemotherapeutic drugs are injected selectively through a catheter into an artery directly supplying the tumor.
1990s – RFA for soft tissue tumors, i.e., bone, breast, kidney, lung and liver cancer. 1997 – Intra-arterial delivery of tumor-killing viruses and gene therapy vectors to the liver. 1997 – HIFU first used to treat prostate cancer. 2012 – Pioneering liver chemoperfusion study reported by Delcath for disseminated liver metastases. [32]
Percutaneous hepatic perfusion (PHP) is a regionalized, minimally-invasive approach to cancer treatment [1] currently undergoing Phase II and Phase III clinical testing.PHP treats a variety of hepatic tumors by isolating the liver and exposing the organ to high-dose chemotherapy.
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