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Salt and water retention, including facial swelling and edema [36] [37] Estrogen is associated with edema, including facial and abdominal swelling. Melanin. Estrogen is known to cause darkening of skin, especially in the face and areolae. [38]
This phenomenon can be seen in various forms like increasing weight gain and swollen belly, legs, or ankles. Water retention is a symptom felt by some women of all backgrounds before their menstruation onset and was listed as one of the most common premenstrual symptoms in addition to cramping and back pain. [ 1 ]
Hormonal imbalance (elevated ratio of estrogen to androgen) during early puberty, either due to decreased androgen production from the adrenals and/or increased conversion of androgens to estrogens, leads to transient gynecomastia in adolescent males. It can occur in up to 65% of adolescents as early as age 10 and peaks at ages 13 and 14.
Liver cirrhosis is another cause, though through lowered metabolism of estrogen, not oversecretion or overconsumption like the aforementioned. It's necessary to know there exist two kinds of hyperestrogenism: Absolute (more concentration than usual of estrogen) and relative (a normal concentration of estrogen, higher with respect to progesterone).
This can detect baseline estrogen in women with amenorrhea or menstrual dysfunction, and to detect the state of hypoestrogenicity and menopause. Furthermore, estrogen monitoring during fertility therapy assesses follicular growth and is useful in monitoring the treatment.
Vaginal estrogen is a form of estrogen that is delivered by intravaginal administration. Vaginally administered estrogens are thereby exerting their effects mainly in the nearby tissue, with more limited systemic effects compared to orally administered estrogens. [ 1 ]