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[84] [85] [86] The preceding side effects of synthetic estrogens do not appear to occur in pregnant women, who already have very high estrogen levels. [84] This suggests that these effects are due to estrogenic activity. [84] Synthetic estrogens have markedly stronger effects on the liver and hepatic protein synthesis than natural estrogens.
As unopposed estrogen therapy (using estrogen alone without progesterone) increases the risk of endometrial hyperplasia and endometrial cancer in women with intact uteruses, estradiol is usually combined with a progestogen like progesterone or medroxyprogesterone acetate to prevent the effects of estradiol on the endometrium.
List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes: [1] [2]. Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia ...
The World Health Organization (WHO) does not recommend the use of combined oral contraceptive pills in women with breast cancer. [41] [97] Since combined oral contraceptive pills contain both estrogen and progestin, they are not recommended to be used in those with hormonally-sensitive cancers, including some types of breast cancer.
The tolerability profile of HDE is worse in men compared to women. Side effects of HDE specific to men may include gynecomastia (breast development), feminization and demasculinization in general (e.g., reduced body hair, decreased muscle mass and strength, feminine changes in fat mass and distribution, and reduced penile and testicular size ...
Women who took estrogen pills had a 14 percent higher risk of developing hypertension than those using skin patches or The post Hormone patches, creams for menopause symptoms may have lower blood ...
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