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Scleroderma is caused by genetic and environmental factors. [ 4 ] [ 5 ] [ 17 ] [ 18 ] Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases; likewise silica , aromatic and chlorinated solvents, ketones , trichloroethylene , welding fumes, and white spirits exposure seems to contribute to the condition in a small ...
No clear cause for scleroderma and systemic sclerosis has been identified. Genetic predisposition appears to be limited, as genetic concordance is small; still, a familial predisposition for autoimmune disease is often seen. Polymorphisms in COL1A2 and TGF-β1 may influence severity and development of the disease.
Questions remain related to diet, lifestyle, exposure to new pathogens -- such as bird flu and COVID-19 -- chemicals like pesticides and plastics and the impact of environmental and genetic ...
Certain individuals are genetically susceptible to developing autoimmune diseases. This susceptibility is associated with multiple genes plus other risk factors. Genetically predisposed individuals do not always develop autoimmune diseases. Three main sets of genes are suspected in many autoimmune diseases. These genes are related to: [17]
The exact causes of autoimmune diseases remain unclear and are likely multifactorial, involving both genetic and environmental influences. [7] While some diseases like lupus exhibit familial aggregation, suggesting a genetic predisposition , other cases have been associated with infectious triggers or exposure to environmental factors, implying ...
Systemic sclerosis (progressive systemic scleroderma), a rare, chronic disease which affects the skin, and in some cases also blood vessels and internal organs. Tuberous sclerosis, a rare genetic disease which affects multiple systems.
Awadhesh Jha, professor of genetic toxicology and ecotoxicology at the University of Plymouth, said: “It is speculative to draw conclusions based on such associations and recommend regulations ...
The mechanisms of genetic and ecological inheritance are also different; whereas genetic inheritance depends on reproduction (e.g., sexual and asexual) where genes are transmitted in one direction from parent to offspring in the same species, the modified environment and its selective pressures caused by ecological inheritance can be handed ...
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