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Liothyronine may be used when there is an impaired conversion of T 4 to T 3 in peripheral tissues. [2] The dose of liothyronine for hypothyroidism is a lower amount than levothyroxine due it being a higher concentrated synthetic medication. [2]
Commonly prescribed thyroid drug levothyroxine was linked with bone mass and bone density loss in a cohort of older adults in a recent study. Common thyroid drug levothyroxine linked to bone mass loss
Thyroid hormone requirements increase during and last throughout pregnancy. [14] As such, pregnant women are recommended to increase to nine doses of levothyroxine each week, rather than the usual seven, as soon as their pregnancy is confirmed. [14] Repeat thyroid function tests should be done five weeks after the dosage is increased. [14]
Desiccated thyroid preparations have a greater variability from batch to batch than synthetic ones. [9] Desiccated thyroid has roughly a 4:1 ratio of thyroxine (T4) to triiodothyronine (T3). In humans, the ratio is 11:1. [10] A combination of various ratios of T4 and T3 might not provide benefits over T4 alone.
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