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Mephedrone, also known as 4-methylmethcathinone, 4-MMC, and 4-methylephedrone, is a synthetic stimulant drug belonging to the amphetamine and cathinone classes. It is commonly referred to by slang names such as drone, [5] M-CAT, [6] white magic, [7] meow meow, and bubble. [8]
4-Methylmethcathinone (mephedrone) 58–62.7: 49.1–51: 118.3–122 [11] [8] [14] [15] [16] Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with ...
In the UK, mephedrone, commonly known as MCAT, is the fourth most commonly used illicit drug among nightclub goers after cannabis, MDMA and cocaine. [7] Based on reports to the American Association of Poison Control Centers , use of bath salts in the US is thought to have increased significantly between 2010 and 2012. [ 7 ]
Such methamphetamine labs are sometimes discovered when emergency personnel respond to fires due to improper handling of volatile or flammable materials. [ 118 ] [ 119 ] Single-pot "shake and bake" syntheses are particularly prone to explode and ignite, and, when abandoned, still pose a severe hazard to firefighters. [ 119 ]
3-Methylmethcathinone (3-MMC), also known as metaphedrone, [4] is a designer drug from the substituted cathinone family. 3-MMC is a monoamine transporter substrate (a substance acted upon by monoamine transporters) that potently releases and inhibits the reuptake of dopamine and norepinephrine, as well as displaying moderate serotonin releasing activity.
Mephedrone especially experienced a somewhat meteoric rise in popularity in 2009 [25] and the resulting media panic resulted in its prohibition in multiple countries. Following this there was a considerable emergence of other cathinones which attempted to mimic the effects of mephedrone, and with a newly attracted customer base, plenty of money ...
Police have arrested a suspect in the unsolved murder of a Honolulu teenager, whose death rocked the high school where her body was discovered almost five decades ago. They said the man arrested ...
Effects of 4-CMC and mephedrone on inhibition of neurotransmitter uptake [3] Drug Uptake Inhibition at DAT. IC 50 (nM) Uptake Inhibition at NET. IC 50 (nM) Uptake Inhibition at SERT. IC 50 (nM) Mephedrone 769 ± 106 319 ± 40 600 ± 99 4-CMC 1014 ± 78 559 ± 57 542 ± 38