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IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or Tac antigen), β (beta) (also called IL-2Rβ, or CD122), and γ (gamma) (also called IL-2Rγ, γ c, common gamma chain, or CD132); these subunits are also parts of receptors for other cytokines.
16183 Ensembl ENSG00000109471 ENSMUSG00000027720 UniProt P60568 P04351 RefSeq (mRNA) NM_000586 NM_008366 RefSeq (protein) NP_000577 NP_032392 Location (UCSC) Chr 4: 122.45 – 122.46 Mb Chr 3: 37.17 – 37.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a ...
Cytokine receptor common subunit gamma also known as interleukin-2 receptor subunit gamma or IL-2RG is a protein that in humans is encoded by the IL2RG gene. [8] The human IL2RG gene is located on the long (q) arm of the X chromosome at position 13.1, from base pair 70,110,279 to base pair 70,114,423.
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [33]
Interleukin receptors are a family of cytokine receptors for interleukins. ... CCR5), MIP-1 receptor, PF4 receptor, M-CSF receptor and NAP-2 receptor belong to GPCR ...
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta and the common gamma chain .
GM-CSF also has some effects on mature cells of the immune system. These include, for example, enhancing neutrophil migration and causing an alteration of the receptors expressed on the cells surface. [7] GM-CSF signals via signal transducer and activator of transcription, STAT5. [8] In macrophages, it has also been shown to signal via STAT3 ...
12984 Ensembl ENSG00000100368 ENSMUSG00000071714 UniProt P32927 P26954 RefSeq (mRNA) NM_000395 NM_001287389 NM_007781 RefSeq (protein) NP_000386 NP_001274318 NP_031807 Location (UCSC) Chr 22: 36.91 – 36.94 Mb Chr 15: 78.17 – 78.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type ...