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LEEP cone biopsy displaying normal cervical epithelium (far left) progressing to borderline koilocytosis, to LSIL, and to HSIL (far right). A squamous intraepithelial lesion (SIL) is an abnormal growth of epithelial cells on the surface of the cervix, commonly called squamous cells.
A low-grade squamous intraepithelial lesion (LSIL or LGSIL) indicates possible cervical dysplasia. LSIL usually indicates mild dysplasia (CIN 1), more than likely caused by a human papillomavirus infection. It is usually diagnosed following a Pap smear. [citation needed] CIN 1 is the most common and most benign form of cervical intraepithelial ...
High-grade squamous intraepithelial lesion Represents a mix of low- and high-grade lesions not easily differentiated by histology; HSIL+ encompasses HSIL, AGC, and cancer; CIN 2 (Grade II) Moderate dysplasia confined to the basal 2/3 of the epithelium; Represents a mix of low- and high-grade lesions not easily differentiated by histology
C. High-grade dysplasia, here called high grade squamous intraepithelial lesion (HSIL) D. Squamous cell carcinoma , infiltrating the stroma (middle and left in image), and HSIL (right in image) Epithelial dysplasia , a term becoming increasingly referred to as intraepithelial neoplasia , is the sum of various disturbances of epithelial ...
Among the Bethesda results: Low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL). An LSIL Pap may correspond to CIN1, and HSIL may correspond to CIN2 and CIN3, [69] but they are results of different tests, and the Pap test results need not match the histologic findings. [medical citation needed]
When examining cytologic specimens, a diagnosis of ASC-US is given if squamous cells are suspicious for low-grade squamous intraepithelial lesion (LSIL) but do not fulfill the criteria. This may be due to limitations in the quality of the specimen, or because the abnormalities in the cells are milder than that seen in LSIL. [ 6 ]
The median rate for all preparations with low-grade squamous intraepithelial lesions using LBPs was 2.9% in 2006, compared with a 2003 median rate of 2.1%. Rates for high-grade squamous intraepithelial lesions (median, 0.5%) and atypical squamous cells have changed little. [32] Abnormal results are reported according to the Bethesda system. [33]
Colposcopy is not generally performed for people with pap test results showing low-grade squamous intraepithelial lesion (LSIL) or less. SILs are an abnormal growth of epithelial cells, known as a lesion, on the surface of the cervix. Unless the person has a visible lesion, colposcopy for this population does not detect a recurrence of cancer. [10]