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Mucocutaneous leishmaniasis is an especially disturbing form of cutaneous leishmaniasis, because it produces destructive and disfiguring lesions of the face. It is most often caused by Leishmania braziliensis, but cases caused by L. aethiopica have also been described. [10] Mucocutaneous leishmaniasis is very difficult to treat.
[2] [8] The disease can present in three main ways: cutaneous, mucocutaneous, or visceral. [2] The cutaneous form presents with skin ulcers, while the mucocutaneous form presents with ulcers of the skin, mouth, and nose. The visceral form starts with skin ulcers and later presents with fever, low red blood cell count, and enlarged spleen and liver.
Leishmania braziliensis, like other species of Leishmania, rely on asexual reproduction in the intermediate mammalian host to greatly increase population density. Such reproduction is often witnessed in mononuclear phagocytes (dendritic cells, monocytes, neutrophils) of the mammalian host, with the macrophages being the target white blood cell of the parasite. [5]
It is estimated that visceral leishmaniasis (VL) affects more than 100 million people worldwide, [37] with 1.5 to 2 million new cases and more than 70,000 deaths each year. [38] As of the 2022 report, there were 50,000 to 90,000 infections worldwide in 2020, and the World Health Organization estimates that only between 25 and 45% of the cases ...
Leishmania / l iː ʃ ˈ m eɪ n i ə,-ˈ m æ n-/ [1] is a parasitic protozoan, a single-celled organism of the genus Leishmania that is responsible for the disease leishmaniasis. [2] [3] [4] They are spread by sandflies of the genus Phlebotomus in the Old World, and of the genus Lutzomyia in the New World.
Brahmachari's cure for visceral leishmaniasis was the urea salt of para-amino-phenyl stibnic acid which he called Urea Stibamine. [117] During the nineteenth century, kala-azar was discovered near moving bodies of water in southeast Asia. [118] Dr. Jean Dow and Dr. William McClure, are credited with finding the cure for the disease in China.
Chronic mucocutaneous candidiasis is an immune disorder of T cells. [4] It is characterized by chronic infections with Candida that are limited to mucosal surfaces, skin, and nails. [5]: 310 It can also be associated with other types of infections, such as human papilloma virus. An association with chromosome 2 has been identified.
Dalecarlia Water Treatment Plant, Washington, D.C. Water treatment is any process that improves the quality of water to make it appropriate for a specific end-use. The end use may be drinking, industrial water supply, irrigation, river flow maintenance, water recreation or many other uses, including being safely returned to the environment.
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