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Roughly one-quarter of the world's population has been infected with M. tuberculosis, [6] with new infections occurring in about 1% of the population each year. [11] However, most infections with M. tuberculosis do not cause disease, [169] and 90–95% of infections remain asymptomatic. [87] In 2012, an estimated 8.6 million chronic cases were ...
M. tuberculosis can also grow on the lipid cholesterol as a sole source of carbon, and genes involved in the cholesterol use pathway(s) have been validated as important during various stages of the infection lifecycle of M. tuberculosis, especially during the chronic phase of infection when other nutrients are likely not available. [47]
In the human skeleton, a tubercle or tuberosity is a protrusion that serves as an attachment for skeletal muscles. The muscles attach by tendons, where the enthesis is the connective tissue between the tendon and bone. [4] For example, the tibial tuberosity creates an attachment point for the ligamentum patellae, or patellar ligament.
A tuberculoma is a clinical manifestation of tuberculosis which conglomerates tubercles into a firm lump, and so can mimic cancer tumors of many types in medical imaging studies. [1] [2] They often arise within individuals in whom a primary tuberculosis infection is not well controlled. [3]
Ghon's complex is a lesion seen in the lung that is caused by tuberculosis. [1] [2] The lesions consist of a Ghon focus along with pulmonary lymphadenopathy within a nearby pulmonary lymph node. A Ghon's complex retains viable bacteria, making them sources of long-term infection, which may reactivate and trigger secondary tuberculosis later in ...
Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB.. The medical standard for active TB is a short course treatment involving a combination of isoniazid, rifampicin (also known as Rifampin), pyrazinamide, and ethambutol for the first two months.
The Mycobacterium tuberculosis complex (MTC or MTBC) is a genetically related group of Mycobacterium species that can cause tuberculosis in humans or other animals. It includes: Mycobacterium tuberculosis; Mycobacterium africanum; Mycobacterium orygis [1] Mycobacterium bovis and the Bacillus Calmette–Guérin strain; Mycobacterium microti ...
Infection by M. tuberculosis remains a serious problem in the world and knowledge of cord factor can be useful in controlling this disease. [24] For example, the glycoprotein known as lactoferrin is able to mitigate cytokine production and granuloma formation brought on by cord factor. [ 47 ]