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  2. Gentamicin - Wikipedia

    en.wikipedia.org/wiki/Gentamicin

    The dose required should be monitored by blood testing. [5] Gentamicin can cause inner ear problems and kidney problems. [5] The inner ear problems can include problems with balance and hearing loss. [5] These problems may be permanent. [5] If used during pregnancy, it can cause harm to the developing fetus. [5]

  3. Area under the curve (pharmacokinetics) - Wikipedia

    en.wikipedia.org/wiki/Area_under_the_curve...

    For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug. [3] AUC becomes useful for knowing the average concentration over a time interval, AUC/t.

  4. Therapeutic drug monitoring - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_drug_monitoring

    3) Regarding dosage adjustment to recommend, this TDM result suggests that a doubled dose of 800 mg daily might be suitable to drive the concentration curve close to target (blue dotted line). Note that this interpretation assumes that the patient's adherence to prescription is good, and that the sample measurement is accurate.

  5. Gentamicin/betamethasone valerate/clotrimazole - Wikipedia

    en.wikipedia.org/wiki/Gentamicin/betamethasone...

    Gentamicin/betamethasone valerate/clotrimazole is a fixed dose combination veterinary drug, sold under the trade name Otomax. [1] It is a suspension for otic use in dogs. The active ingredients are gentamicin, betamethasone valerate and clotrimazole. This drug product is used for treatment of acute external otitis. It is also used for the ...

  6. Antimicrobial pharmacodynamics - Wikipedia

    en.wikipedia.org/wiki/Antimicrobial_pharmacodynamics

    It has been suggested that an alteration of DNA function is possibly responsible for the post-antibiotic effect following the observation that most inhibitors of protein and nucleic acid synthesis (aminoglycosides, fluoroquinolones, tetracyclines, clindamycin, certain newer macrolides/ketolides, and rifampicin and rifabutin) induce long-term ...

  7. Trough level - Wikipedia

    en.wikipedia.org/wiki/Trough_level

    In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is ...

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