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Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [ 5 ] of the cell nucleus.
Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal). It is caused by the JC virus, which is normally present and kept under control by the immune system. The ...
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First released as the Cleveland Clinic Bulletin in 1931, the publication was renamed the Cleveland Clinic Quarterly in 1932 and later rebranded as the CCJM in 1987. [ 1 ] CCJM is a peer-reviewed medical publication distributed monthly to over 123,000 healthcare professionals, including internists, hospitalists, cardiologists , endocrinologists ...
Joseph R. Berger (born April 19, 1951) is an American internist and neurologist who is known [1] [non-primary source needed] [2] [non-primary source needed] for his research interests in progressive multifocal leukoencephalopathy (PML), the neurological complications of HIV/AIDS, multiple sclerosis, and other inflammatory disorders of the brain.
Medical News Today is a web-based outlet for medical information and news, targeted at both the general public and physicians. All posted content is available online (>250,000 articles as of January 2014), and the earliest available article dates from May 2003. The website was founded in 2003 by Alastair Hazell and Christian Nordqvist. [1]
Plates vi & vii of the Edwin Smith Papyrus (around the 17th century BC), among the earliest medical guidelines. A medical guideline (also called a clinical guideline, standard treatment guideline, or clinical practice guideline) is a document with the aim of guiding decisions and criteria regarding diagnosis, management, and treatment in specific areas of healthcare.