Search results
Results From The WOW.Com Content Network
An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have four nuclei [5] and are 150–200 μm in diameter. When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 μm in diameter occur. These may have dozens of nuclei, and typically express major ...
High levels of calcium, magnesium, phosphate and products of collagen will be released into the extracellular fluid as the osteoclasts tunnel into the mineralized bone. Osteoclasts are prominent in the tissue destruction found in psoriatic arthritis and rheumatological disorders. [3] The human body is in a constant state of bone remodeling. [4]
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
Foreign-body giant cells form when a subject is exposed to a foreign substance. Exogenous substances can include talc or sutures. As with other types of giant cells, epithelioid macrophages fusing together causes these giant cells to form and grow. [13] In this form of giant cell, the nuclei are arranged in an overlapping manner.
Bone is broken down by osteoclasts, and rebuilt by osteoblasts, both of which communicate through cytokine (TGF-β, IGF) signalling. Ossification (also called osteogenesis or bone mineralization) in bone remodeling is the process of laying down new bone material by cells named osteoblasts. It is synonymous with bone tissue formation. [1]
The periosteal cells distal to (at the far end of) the fracture gap develop into osteoblasts, which form woven bone [citation needed] through bone resorption of calcified cartilage and recruitment of bone cells and osteoclasts. [4] The fibroblasts within the granulation tissue develop into chondroblasts which also form hyaline cartilage.
The cell body varies in size from 5–20 micrometers in diameter and contain 40–60 cell processes per cell, [4] with a cell to cell distance between 20–30 micrometers. [3] A mature osteocyte contains a single nucleus that is located toward the vascular side and has one or two nucleoli and a membrane. [ 5 ]
Osteoclasts break down bone tissue, and along with osteoblasts and osteocytes form the structural components of bone. In the hollow within bones are many other cell types of the bone marrow . Components that are essential for osteoblast bone formation include mesenchymal stem cells (osteoblast precursor) and blood vessels that supply oxygen and ...