Search results
Results From The WOW.Com Content Network
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
The sale of mouse animal models began in 1933 with early sales to the United States Public Health Service and The Jackson Laboratory now provides a high proportion of the mice used in biomedical research [16] In particular, the C57BL/6J strain, which is widely used and cited is maintained at The Jackson Laboratory.
Some laboratory mouse strains, such as C57BL/6, are domesticated from M. m. domesticus. [1] Distribution
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
Approximately 60% of FVB Mice regardless of sex survive to two years of age. [6] By this point, approximately 60% of surviving mice show tumors/lesions. Some sudden deaths are observed in younger animals, but most die at 15 months or older. Two years is a common life expectancy in wild-type house mice.
This black coloured mouse is a sub-strain of C57BL/6 created in 1921 by C. C. Little at the Bussey Institute for Research in Applied Biology. It is used widely in genetics, toxicology and as pet. [20] The majority of the genome is from M. m. domesticus, while smaller portion is of M. m. molossinus. [21]
C57BL/6 was created by Clarence Little, the first director and founder of JAX. However, he created the strain in 1921 (see here on the JAX site), whereas the Jackson Labs didn't come into being until 1929. In addition, JAX may be the largest supplier of C57BL/6J, but it probably is not the largest supplier of some other substrains, such as ...
Charles River was founded in 1947 by Henry Foster, a young veterinarian who purchased one thousand rat cages from a Virginia farm and set up a one-person laboratory in Boston overlooking the Charles River. To fulfill the regional need for laboratory animal models, he bred, fed, and cared for the animals and personally delivered them to local ...