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Aside from no improvement in your numbers, about 5% of individuals discontinue metformin due to side effects, she adds. The most common side effects are related to the digestive system such as gas ...
As noted, timing your metformin dosage is crucial for mitigating the risk — and overall severity — of side effects. But what are those side effects exactly? The most common side effects of ...
A Cochrane review, though, found that metformin was only slightly effective for decreasing androgen levels in women with PCOS. [125] Metformin also has significant effects on the gut microbiome, such as its effect on increasing agmatine production by gut bacteria, but the relative importance of this mechanism compared to other mechanisms is ...
One theory is that metformin has anti-tumor side effects because it lowers insulin levels and keeps tumor cells from multiplying. Still, more research is needed. ... Indeed, many women with PCOS ...
An example of this is the repurposing of the antimineralocorticoid and diuretic spironolactone, which was found to produce feminization and gynecomastia as side effects, for use as an antiandrogen in the treatment of androgen-dependent conditions like acne and hirsutism in women. [1] Metformin also causes off-target activity. [citation needed]
The most common side effects include hypoglycemia (low blood glucose levels) when used in combination with insulin or a sulphonylurea and vulvovaginal candidiasis (thrush, a fungal infection of the female genital area caused by Candida).