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  2. Gel electrophoresis - Wikipedia

    en.wikipedia.org/wiki/Gel_electrophoresis

    DNA gel electrophoresis is usually performed for analytical purposes, often after amplification of DNA via polymerase chain reaction (PCR), but may be used as a preparative technique prior to use of other methods such as mass spectrometry, RFLP, PCR, cloning, DNA sequencing, or southern blotting for further characterization.

  3. Gel electrophoresis of nucleic acids - Wikipedia

    en.wikipedia.org/wiki/Gel_electrophoresis_of...

    The negative charge of its phosphate backbone moves the DNA towards the positively charged anode during electrophoresis. However, the migration of DNA molecules in solution, in the absence of a gel matrix, is independent of molecular weight during electrophoresis, i.e. there is no separation by size without a gel matrix. [12]

  4. Base pair - Wikipedia

    en.wikipedia.org/wiki/Base_pair

    The following DNA sequences illustrate pair double-stranded patterns. By convention, the top strand is written from the 5′-end to the 3′-end; thus, the bottom strand is written 3′ to 5′. A base-paired DNA sequence: ATCGATTGAGCTCTAGCG TAGCTAACTCGAGATCGC The corresponding RNA sequence, in which uracil is substituted for thymine in the RNA ...

  5. Nucleic acid structure - Wikipedia

    en.wikipedia.org/wiki/Nucleic_acid_structure

    DNA structure and bases A-B-Z-DNA Side View. Tertiary structure refers to the locations of the atoms in three-dimensional space, taking into consideration geometrical and steric constraints. It is a higher order than the secondary structure, in which large-scale folding in a linear polymer occurs and the entire chain is folded into a specific 3 ...

  6. DNA - Wikipedia

    en.wikipedia.org/wiki/DNA

    The double-stranded structure of DNA provides a simple mechanism for DNA replication. Here, the two strands are separated and then each strand's complementary DNA sequence is recreated by an enzyme called DNA polymerase. This enzyme makes the complementary strand by finding the correct base through complementary base pairing and bonding it onto ...

  7. Nucleic acid sequence - Wikipedia

    en.wikipedia.org/wiki/Nucleic_acid_sequence

    DNA sequencing is the process of determining the nucleotide sequence of a given DNA fragment. The sequence of the DNA of a living thing encodes the necessary information for that living thing to survive and reproduce. Therefore, determining the sequence is useful in fundamental research into why and how organisms live, as well as in applied ...

  8. Polyelectrolyte theory of the gene - Wikipedia

    en.wikipedia.org/wiki/Polyelectrolyte_theory_of...

    In biochemistry, the structure of a biomolecule dictates its function, and therefore changes in structure cause changes in function. [14] To work as a unit of inheritance, the genetic biopolymer must maintain shape and, therefore, physical and chemical consistency, regardless of the information the structure encodes. DNA is such a molecule.

  9. Sense (molecular biology) - Wikipedia

    en.wikipedia.org/wiki/Sense_(molecular_biology)

    An individual strand of DNA is referred to as positive-sense (also positive (+) or simply sense) if its nucleotide sequence corresponds directly to the sequence of an RNA transcript which is translated or translatable into a sequence of amino acids (provided that any thymine bases in the DNA sequence are replaced with uracil bases in the RNA ...