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Initiated free radical research during post doctoral studies and has continued research interest in the areas of free radicals and oxidative stress in biology and medicine. His lab is active in studying the health effects associated with free radicals of oxygen, oxidative stress and role of antioxidants in patho-physiological processes.
Although research in vitro indicates polyphenols are good antioxidants and probably influence the ORAC value, antioxidant effects in vivo are probably negligible or absent. [3] [10] By non-antioxidant mechanisms still undefined, flavonoids and other polyphenols may reduce the risk of cardiovascular disease and cancer. [11]
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
The nutrient has been shown to help guard against breast cancer, while a diet rich in vitamin A has been linked to a lower risk for squamous cell carcinoma, a common form of skin cancer.
Antioxidants are helpful in reducing and preventing damage from free radical reactions because of their ability to donate electrons which neutralize the radical without forming another. Vitamin C , for example, can lose an electron to a free radical and remain stable itself by passing its unstable electron around the antioxidant molecule.
Antioxidants & Redox Signaling is a peer-reviewed scientific journal covering reduction–oxidation (redox) signaling and antioxidant research. It covers topics such as reactive oxygen species/reactive nitrogen species (ROS/RNS) as messengers gaseous signal transducers, hypoxia and tissue oxygenation, microRNA, prokaryotic systems, and lessons from plant biology.
Antioxidants is a peer-reviewed open-access scientific journal that covers various areas of antioxidants research, including biosynthesis, pharmacodynamics, and synthetic antioxidants. It is published by MDPI and was established in 2012. The editor-in-chief is Stanley Omaye (University of Nevada).
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli in colorectal cancer, retinoblastoma (Rb). and von Hippel–Lindau tumor suppressor (VHL), as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of inflammatory responses.