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  2. Blood sugar regulation - Wikipedia

    en.wikipedia.org/wiki/Blood_sugar_regulation

    If the blood glucose level falls to dangerously low levels (as during very heavy exercise or lack of food for extended periods), the alpha cells of the pancreas release glucagon, a peptide hormone which travels through the blood to the liver, where it binds to glucagon receptors on the surface of liver cells and stimulates them to break down glycogen stored inside the cells into glucose (this ...

  3. Pancreatic beta cell function - Wikipedia

    en.wikipedia.org/wiki/Pancreatic_beta_cell_function

    It remains an unsolved question if impaired pancreatic beta cell function or hypersecretion of insulin represent the primary event in the pathogenesis of type 2 diabetes. [6] Both scenarios may be cause and consequence, and it has been postulated that the direction of causality depends on the respective subtype of diabetes. [ 6 ]

  4. Pancreas - Wikipedia

    en.wikipedia.org/wiki/Pancreas

    The pancreas maintains constant blood glucose levels (shown as the waving line). When the blood glucose level is too high, the pancreas secretes insulin and when the level is too low, the pancreas secretes glucagon. Cells within the pancreas help to maintain blood glucose levels (homeostasis). The cells that do this are located within the ...

  5. Hyperglycemia - Wikipedia

    en.wikipedia.org/wiki/Hyperglycemia

    Glucose levels vary before and after meals, and at various times of day; the definition of "normal" varies among medical professionals. In general, the normal range for most people (fasting adults) is about 4 to 6 mmol/L or 80 to 110 mg/dL. (where 4 mmol/L or 80 mg/dL is "optimal".)

  6. Diabetes - Wikipedia

    en.wikipedia.org/wiki/Diabetes

    Diabetes, also known as diabetes mellitus, is a group of common endocrine diseases characterized by sustained high blood sugar levels. [10] [11] Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. [12]

  7. Beta cell - Wikipedia

    en.wikipedia.org/wiki/Beta_cell

    When the glucose concentration outside the cell is high, glucose molecules move into the cell by facilitated diffusion, down its concentration gradient through the GLUT2 transporter. [15] Since beta cells use glucokinase to catalyze the first step of glycolysis, metabolism only occurs around physiological blood glucose levels and above. [4]

  8. Glucagon - Wikipedia

    en.wikipedia.org/wiki/Glucagon

    The pancreas releases glucagon when the amount of glucose in the bloodstream is too low. Glucagon causes the liver to engage in glycogenolysis: converting stored glycogen into glucose, which is released into the bloodstream. [3] High blood-glucose levels, on the other hand, stimulate the release of insulin.

  9. Glucose - Wikipedia

    en.wikipedia.org/wiki/Glucose

    Each of these situations can be caused by persistently high elevations of blood glucose levels, through pancreatic burnout and insulin resistance. The pancreas is the organ responsible for the secretion of the hormones insulin and glucagon. [127] Insulin is a hormone that regulates glucose levels, allowing the body's cells to absorb and use ...

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