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Acquired asplenia occurs for several reasons: . Following splenectomy due to splenic rupture from trauma or because of tumor; After splenectomy with the goal of interfering with splenic function, as a treatment for diseases (e.g. idiopathic thrombocytopenic purpura, thalassemia, spherocytosis), in which the spleen's usual activity exacerbates the disease
The spleen is an important immunological organ that acts as a filter for red blood cells, triggers phagocytosis of invaders, and mounts an immunological response when necessary. [2] Lack of a spleen, called asplenia, can occur by autosplenectomy or the surgical counterpart, splenectomy. Asplenia can increase susceptibility to infection. [3]
The spleen is an important organ in regard to immunological function due to its ability to efficiently destroy encapsulated bacteria. Therefore, removal of the spleen runs the risk of overwhelming post-splenectomy infection , a medical emergency and rapidly fatal disease caused by the inability of the body's immune system to properly fight ...
The spleen, located on the upper left side of the abdomen next to the stomach, is significantly smaller than the liver, between 2.4 to 3 pounds lighter, and is roughly the size of a fist.
These types of antibodies and complement are immune substances called opsonizers, molecules that bind to the surface of bacteria to facilitate phagocytosis. When the spleen is no longer present ( asplenia ), IgG and C3b are still bound to bacteria, but they cannot be removed from the blood circulation due to the loss of the splenic macrophages.
However, he questioned if it was a rare genetic condition called Gaucher disease, which involves a buildup of fatty cells in the liver, spleen, and occasionally the bone marrow. (This happens ...
A Florida doctor who is accused of removing an Alabama man’s liver instead of the spleen, resulting in “immediate and catastrophic death,” had his medical license suspended.. In an emergency ...
Wandering spleen is most commonly diagnosed in young children [3] as well as women between the ages of 20 and 40. [6] Even so, the disease is very rare and fewer than 500 occurrences of the disease have been reported as of 2005, [3] of which around 148 (including both children and adult cases) were documented to have been from between 1960 and ...