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Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc , l-myc , and n-myc . c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.
These factors bind to promoter regions of DNA and regulate the transcription of oncogenic genes: MYC: The MYC family of transcription factors is one of the most well-known drivers of transcriptional addiction. In cancers, MYC regulates genes involved in cell cycle progression, metabolism, and survival, making it a prime target for cancer therapies.
The MYCN gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix domain. This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. [5] N-Myc is highly expressed in the fetal brain and is critical for normal brain development. [6]
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. [ 5 ] [ 6 ] MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.
17428 Ensembl ENSG00000070444 ENSMUSG00000000282 UniProt Q99583 O08789 RefSeq (mRNA) NM_020310 NM_010813 RefSeq (protein) NP_064706 NP_034943 Location (UCSC) Chr 17: 2.38 – 2.4 Mb Chr 11: 74.72 – 74.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse MNT (Max-binding protein MNT) is a Max-binding protein that is encoded by the MNT gene Function The Myc Mad network comprises a ...
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor.
It is therefore included in the bHLHZ family of transcription factors. It is able to form homodimers with other MAX proteins and heterodimers with other transcription factors, including Mad, Mxl1 and Myc. The homodimers and heterodimers compete for a common DNA target site (the E-box) in a gene promoter zone. Rearrangement of dimers (e.g., Mad ...
Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. These transcription factors are critical to making sure that genes are expressed in the right cell at the right time and in the right amount, depending on the changing requirements of the organism.