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Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc , l-myc , and n-myc . c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.
The MYCN gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix domain. This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. [5] N-Myc is highly expressed in the fetal brain and is critical for normal brain development. [6]
It is therefore included in the bHLHZ family of transcription factors. It is able to form homodimers with other MAX proteins and heterodimers with other transcription factors, including Mad, Mxl1 and Myc. The homodimers and heterodimers compete for a common DNA target site (the E-box) in a gene promoter zone. Rearrangement of dimers (e.g., Mad ...
Transcription factor glossary; ... [32] [33] One example is the Myc oncogene, which has important roles in cell growth and apoptosis. [34] Pathogenesis
These factors bind to promoter regions of DNA and regulate the transcription of oncogenic genes: MYC: The MYC family of transcription factors is one of the most well-known drivers of transcriptional addiction. In cancers, MYC regulates genes involved in cell cycle progression, metabolism, and survival, making it a prime target for cancer therapies.
Myc family: The Myc family of transcription factors are proto-oncogenes implicated in cancer. Yamanaka et al. and Jaenisch et al. demonstrated that c-myc is a factor implicated in the generation of mouse iPS cells and Yamanaka et al. demonstrated it was a factor implicated in the generation of human iPS cells.
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. [ 5 ] [ 6 ] MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.
MYC , a gene that codes for a transcription factor Myc, is important in regulating mammalian cell proliferation and apoptosis. In 1991, researchers tested whether c-Myc could bind to DNA by dimerizing it to E12.