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Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
SB-366791 is a drug which acts as a potent and selective blocker of the TRPV1 ion channel. It has analgesic effects in animal studies, and is used in research into pain and inflammation. [ 1 ] [ 2 ] [ 3 ]
Cimetidine was first marketed in the United Kingdom in 1976, and in the U.S. in August 1977; therefore, it took 12 years from initiation of the H 2 receptor antagonist program to commercialization. By 1979, Tagamet was being sold in more than 100 countries and became the top-selling prescription product in the U.S., Canada, and several other ...
Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. [4]
Since Tums is an over-the-counter drug, it is not considered a pharmaceutical-grade treatment (does not require a prescription). Prescription strength acid reflux medications often contain proton-pump inhibitors (PPI) or histamine H 2 receptor blockers (H 2 blockers, H 2 antagonists). [5]
Benadryl is available without a prescription. Dogs on other medications, ... If your dog is 50 pounds, for example, give him 2 tablets (50 mg total) and see how he responds before giving him the ...
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