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  2. Clostridioides difficile infection - Wikipedia

    en.wikipedia.org/wiki/Clostridioides_difficile...

    Clostridioides difficile infection [5] (CDI or C-diff), also known as Clostridium difficile infection, is a symptomatic infection due to the spore-forming bacterium Clostridioides difficile. [6] Symptoms include watery diarrhea, fever, nausea, and abdominal pain. [1] It makes up about 20% of cases of antibiotic-associated diarrhea. [1]

  3. Clostridioides difficile - Wikipedia

    en.wikipedia.org/wiki/Clostridioides_difficile

    Clostridioides difficile (syn. Clostridium difficile) is a bacterium known for causing serious diarrheal infections, and may also cause colon cancer. [4] [5] It is known also as C. difficile, or C. diff (/ s iː d ɪ f /), and is a Gram-positive species of spore-forming bacteria. [6]

  4. Colitis - Wikipedia

    en.wikipedia.org/wiki/Colitis

    The signs and symptoms of colitis are quite variable and dependent on the cause of the given colitis and factors that modify its course and severity. [2]Common symptoms of colitis may include: mild to severe abdominal pains and tenderness (depending on the stage of the disease), persistent hemorrhagic diarrhea with pus either present or absent in the stools, fecal incontinence, flatulence ...

  5. Clostridioides difficile toxin B - Wikipedia

    en.wikipedia.org/wiki/Clostridioides_difficile...

    Hence, this leads to tumor necrosis factor α (TNF α) and proinflammatory interleukins being established as the major causative agents of pseudomembranous colitis (PMC) and antibiotic-associated diarrhea (AAD). [2] [3] [43] The involvement of toxin A and—most importantly—toxin B is the key element that determines the disease caused by C ...

  6. Enterocolitis - Wikipedia

    en.wikipedia.org/wiki/Enterocolitis

    Common clinical manifestations of enterocolitis are frequent diarrheal defecations, with or without nausea, vomiting, abdominal pain, fever, chills, and alteration of general condition. General manifestations are given by the dissemination of the infectious agent or its toxins throughout the body, or – most frequently – by significant ...

  7. Clostridioides difficile toxin A - Wikipedia

    en.wikipedia.org/wiki/Clostridioides_difficile...

    The toxins function by damaging the intestinal mucosa and cause the symptoms of C. difficile infection, including pseudomembranous colitis. TcdA is one of the largest bacterial toxins known. With a molecular mass of 308 kDa, it is usually described as a potent enterotoxin, [3] but it also has some activity as a cytotoxin. [4]

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