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The initial double helix model discovered, now termed B-form DNA is by far the most common conformation in cells. [12] Two additional rarer helical conformations that also naturally occur were identified in the 1970s: A-form DNA , and Z-form DNA .
These include genotoxicity testing, human biomonitoring and molecular epidemiology, ecogenotoxicology, as well as fundamental research in DNA damage and repair. [15] For example, Swain and Rao, using the comet assay [ 16 ] reported marked increases in several types of DNA damages in rat brain neurons and astrocytes during aging , including ...
Epigenetic alterations can accompany DNA repair of oxidative damage or double-strand breaks. In human cells, oxidative DNA damage occurs about 10,000 times a day and DNA double-strand breaks occur about 10 to 50 times a cell cycle in somatic replicating cells (see DNA damage (naturally occurring)). The selective advantage of DNA repair is to ...
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Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains ...