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Studies have shown that SNRIs as well as SSRIs have significant anti-inflammatory action on microglia [55] in addition to their effect on serotonin and norepinephrine levels. As such, it is possible that an additional mechanism of these drugs that acts in combination with the previously understood mechanism exist.
For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI. SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs, and TCAs), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders.
In addition, the augmentation of a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor with lisdexamfetamine, a norepinephrine–dopamine releasing agent, recently failed to separate from placebo in phase III clinical trials of individuals with treatment-resistant depression, and clinical development was ...
SNRIs are another class of modern antidepressants. Common SNRIs include Cymbalta (duloxetine), Effexor XR (venlafaxine) and Pristiq (desvenlafaxine). Tricyclic antidepressants (TCAs).
Antidepressants: the most common prescription medication among cool people like artists, fictional type As, film protagonists and yourself. Your Guide to Every Antidepressant: SSRIs, SNRIs, TCAs ...
Other antidepressants, including other SSRIs, SNRIs and tricyclic antidepressants. Antipsychotic and antianxiety medications such as pimozide and benzodiazepines, and anticonvulsants like gabapentin.
Several classes of antidepressants have shown efficacy for this disorder, with SSRIs and SNRIs used first-line. Paroxetine, sertraline, and fluoxetine are FDA-approved for panic disorder, while fluvoxamine, escitalopram, and citalopram are also considered effective for them. SNRI venlafaxine is also approved for this condition.
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the ...