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The lecithin–sphingomyelin ratio is a marker of fetal lung maturity. The outward flow of pulmonary secretions from the fetal lungs into the amniotic fluid maintains the level of lecithin and sphingomyelin equally until 32–33 weeks gestation, when the lecithin concentration begins to increase significantly while sphingomyelin remains nearly the same.
Fetal lung development can be tested by sampling the amount of surfactant in the amniotic fluid obtained via amniocentesis. [9] Several tests are available, including the lecithin-sphingomyelin ratio (" L/S ratio "), the presence of phosphatidylglycerol (PG), and the surfactant/albumin (S/A) ratio . [ 9 ]
An amniocentesis is a procedure in which a sample of amniotic fluid is aspirated using a needle that is inserted into the abdomen guided by ultrasound. [1] The sample is then tested, and can help doctors diagnose genetic disorders, birth defects, or other fetal health problems.
Amniotic fluid is removed from the mother by an amniocentesis procedure, where a long needle is inserted through the abdomen into the amniotic sac, using ultrasound guidance such that the fetus is not harmed. Amniocentesis is a low risk procedure, with risk of pregnancy loss between 1 in 1,500 – 1 in 700 procedures.
Fetal lung maturity is associated with how much surfactant the fetus is producing. Reduced production of surfactant indicates decreased lung maturity and is a high risk factor for infant respiratory distress syndrome. [33] Typically a lecithin:sphingomyelin ratio greater than 1.5 is associated with increased lung maturity.
Pathophysiology of the amniotic fluid embolism. An amniotic fluid embolism (AFE) is a life-threatening childbirth emergency in which amniotic fluid enters the blood stream of the mother, triggering a serious reaction which results in cardiorespiratory (heart and lung) collapse and massive bleeding (coagulopathy).
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Expand on indications for amniocentesis for genetic diagnosis purposes; Elaborate on who the procedure is offered to and why and the different scenarios a pregnant person may receive the procedure; Compare and contrast alternatives to amniocentesis for genetic diagnosis and pros/cons of each in relation to amniocentesis; Lung development