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Serum vitamin B 12 is a medical laboratory test that measure vitamin B 12 only in the blood binding to both transcobalamins. [1] Most of the time, 80–94% of vitamin B 12 in the blood binds to haptocorrin, while only 6–20% is binds to transcobalamin ll. [2] Only transcobalamin ll is "active" and can be used by the body. [1]
The Schilling test was a medical investigation used for patients with vitamin B 12 (cobalamin) deficiency. [1] The purpose of the test was to determine how well a patient is able to absorb B12 from their intestinal tract. The test is now considered obsolete and is rarely performed, and is no longer available at many medical centers.
Diagnosing Vitamin B12 Deficiency and Cancer [38] If cancer is suspected as the cause of vitamin B12 deficiency, several diagnostic steps are necessary: Blood Tests : A simple blood test can measure vitamin B12 levels, along with other markers such as homocysteine and methylmalonic acid, which may also indicate a deficiency.
Vitamin B 12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. [2] It is one of eight B vitamins.It is required by animals, which use it as a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. [3]
The Schilling test distinguished PA from other forms of B 12 deficiency, [50] specifically, from Imerslund–Gräsbeck syndrome, a B 12-deficiency caused by mutations in CUBN that codes for cubilin the cobalamin receptor. [1] Vitamin B12 deficiency is also prevalent in patients having Crohn's disease (CD) so it should be differentiated. [62]
Vitamin deficiency is the condition of a long-term lack of a vitamin.When caused by not enough vitamin intake it is classified as a primary deficiency, whereas when due to an underlying disorder such as malabsorption it is called a secondary deficiency.
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The same cells in the stomach that produce gastric hydrochloric acid, the parietal cells, also produce a molecule called the intrinsic factor (IF), which binds the B 12 after its release from haptocorrin by digestion, and without which only 1% of vitamin B 12 is absorbed. Intrinsic factor (IF) is a glycoprotein, with a molecular weight of 45 kDa.