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The endoplasmic reticulum is found in most eukaryotic cells and forms an interconnected network of flattened, membrane-enclosed sacs known as cisternae (in the RER), and tubular structures in the SER. The membranes of the ER are continuous with the outer nuclear membrane. The endoplasmic reticulum is not found in red blood cells, or spermatozoa.
He was also responsible for naming the endoplasmic reticulum, conducting work on the 9 + 2 microtubule structure in the axoneme of cilia, and coining the term "microtrabecular lattice." In collaborations with other scientists, he contributed to the understanding of cellular structures and concepts such as compartmentalization , flagella ...
The prize was granted for his innovations in electron microscopy and cell fractionation which together laid the foundations of modern molecular cell biology, [3] the most notable discovery being the ribosomes of the endoplasmic reticulum – which he first described in 1955.
This was the discovery of endoplasmic reticulum (a Latin for "fishnet"). [3] In 1949, he became Director of the Jules Bordet Institute for Cancer Research and Treatment (Institut Jules Bordet) and Professor at the Faculty of Medicine of the Free University of Brussels, where he was Emeritus in 1971.
Valosin-containing protein (VCP) or transitional endoplasmic reticulum ATPase (TER ATPase) also known as p97 in mammals and CDC48 in S. cerevisiae, is an enzyme that in humans is encoded by the VCP gene. [5] [6] [7] The TER ATPase is an ATPase enzyme present in all eukaryotes and archaebacteria.
The signal recognition particle (SRP) is an abundant, cytosolic, universally conserved ribonucleoprotein (protein-RNA complex) that recognizes and targets specific proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes. [1]
Association and maturation of rRNA and r-proteins result in the formation of the 40S (small) and 60S (large) subunits of the complete ribosome. These are exported through the nuclear pore complexes to the cytoplasm, where they remain free or become associated with the endoplasmic reticulum, forming the rough endoplasmic reticulum (RER). [20] [21]
Ribosomes can be found either floating freely or bound to a membrane (the rough endoplasmatic reticulum in eukaryotes, or the cell membrane in prokaryotes). [ 11 ] Plastids : Plastid are membrane-bound organelle generally found in plant cells and euglenoids and contain specific pigments , thus affecting the colour of the plant and organism.