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Juvenile Myoclonic Epilepsy (JME), also referred to as Janz Syndrome and Impulsive Petit Mal, is a form of epilepsy that is characterized by absence, Myoclonic, and Generalized Tonic-Clonic Seizures. This epilepsy variant is marked by its idiopathic and hereditary characteristics, as well as its generalization across seizures.
Ethosuximide, sold under the brand name Zarontin among others, is a medication used to treat absence seizures. [4] It may be used by itself or with other antiseizure medications such as valproic acid. [4]
Juvenile myoclonic epilepsy (JME), also known as Janz syndrome or impulsive petit mal, is a form of hereditary, idiopathic generalized epilepsy, [1] representing 5–10% of all epilepsy cases.
A spike-and-wave discharge is a regular, symmetrical, generalized EEG pattern seen particularly during absence epilepsy, also known as ‘petit mal’ epilepsy. [1] The basic mechanisms underlying these patterns are complex and involve part of the cerebral cortex, the thalamocortical network, and intrinsic neuronal mechanisms. [2]
Paramethadione (brand name Paradione) was originally approved by the U.S. Food and Drug Administration (FDA) in 1949, as a second-line treatment for petit mal and absence seizures. [10] Paramethadione was ultimately discontinued in 1994 due to safety and efficacy concerns, [ 11 ] [ 12 ] such as being associated with fetal trimethadione syndrome ...
AG is used as an anticonvulsant in the treatment of petit mal epilepsy and as a steroidogenesis inhibitor in the treatment of Cushing's syndrome, postmenopausal breast cancer, and prostate cancer. [ 15 ] [ 6 ] [ 12 ] [ 7 ] It is also used to treat secondary hyperaldosteronism , edema , adrenocortical carcinoma , and ectopic adrenocorticotropic ...
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[3] [7] If it is a person's first seizure and it was "provoked", or caused by another condition, treatment of the cause is usually enough to treat the seizure. [3] If the seizure is "unprovoked", brain imaging is abnormal, and/or EEG is abnormal, starting anti-seizure medications is generally recommended. [3] [7] [14]
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