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Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. [44] About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. [44] The terminal elimination half-lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively. [44]
Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5- carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [ 17 ] and has been a model for the continuing development of several other ARBs.
Egypt Today was first published in 1979. [2] It covers Egyptian current affairs and some international news. The magazine is published by IBA media, which also publishes Business Today Egypt, another monthly magazine. [3] [4] Both magazines are based in Cairo. [3]
Al-Akhbar (Arabic: الأخبار; The News in English) is an Arabic daily newspaper based in Egypt. [1] It is a state-owned semi-official newspaper. [2] [3]
Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [8] It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs).
Egypt is a lower-middle-income country with high levels of unemployment. Despite the government's efforts to further the economy, 32.5% of Egyptians live in extreme poverty. With an increasing population and changing socioeconomic environment, Egypt faces great challenges in adapting to such developments in terms of healthcare facilities. [21]
Biphenyl (also known as diphenyl, phenylbenzene, 1,1′-biphenyl, lemonene [4] or BP) is an organic compound that forms colorless crystals. Particularly in older literature, compounds containing the functional group consisting of biphenyl less one hydrogen (the site at which it is attached) may use the prefixes xenyl or diphenylyl .
Business Today Egypt (also known as BT) is an English business magazine which is published monthly in Cairo, Egypt by Egyptian Media Group. [1] [2] It is the only independent business magazine in the country. The magazine models Fortune and Business Week magazines. [3]