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Types of retinopathy caused by drug abuse include maculopathy, Saturday night retinopathy, and talc retinopathy. Common symptoms include temporary and permanent vision loss, blurred vision, and night blindness. Substances commonly associated with this condition include poppers, heroin, cocaine, methamphetamine, tobacco, and alcohol. [1]
The pharmacodynamics of cocaine involve the complex relationships of neurotransmitters (inhibiting monoamine uptake in rats with ratios of about: serotonin:dopamine = 2:3, serotonin:norepinephrine = 2:5). [110] [15] The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter protein.
Cocaine is a nonselective, reuptake inhibitor of the norepinephrine, serotonin, and dopamine transporters. This thwarts the absorption of these chemicals into the presynaptic terminal [ 27 ] and allows a large concentration of dopamine, serotonin and norepinephrine to build up in the synaptic cleft.
Cocaine alters one's state of consciousness. Cocaine affects the neurotransmitters that nerves use to communicate with each other. Cocaine inhibits the reuptake of norepinephrine, serotonin, dopamine, and other neurotransmitters in the synapse, resulting in an altered state of consciousness or a "high" (Aldridge, D., & Fachner, J. ö. 2005).
Cocaine- and amphetamine-regulated transcript, also known as CART, is a neuropeptide protein that in humans is encoded by the CARTPT gene. [ 1 ] [ 2 ] CART appears to have roles in reward, feeding, and stress, [ 3 ] and it has the functional properties of an endogenous psychostimulant .
How does pink cocaine affect someone? It can be hard to determine how the drug cocktail may affect someone after ingesting it. WebMD said this is due to several factors: the types of drugs mixed ...
Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [188] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...
TikTokers, news outlets and Twitter feeds are buzzing over ‘cocaine sharks,’ with most out-of-staters dubbing it “another reason not to go to Florida.” 'Cocaine sharks' probably aren't as ...