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Pando was founded in 2017 by Dr Barney Gilbert, Lydia Yarlott and Philip Mundy with a vision of connecting healthcare for everyone. The company has raised approximately $10m USD in venture capital financing, including from Australian investment firm Skip Capital [1] to allow international expansion in India and Australia.
When individuals take insulin without needing it, to purposefully induce hypoglycemia, this is referred to as surreptitious insulin use or factitious hypoglycemia. [ 3 ] [ 2 ] [ 24 ] Some people may use insulin to induce weight loss, whereas for others this may be due to malingering or factitious disorder , which is a psychiatric disorder . [ 24 ]
The most common cause of hypoglycemia is medications used to treat diabetes mellitus such as insulin and sulfonylureas. [ 9 ] [ 10 ] Risk is greater in diabetics who have eaten less than usual, exercised more than usual or have drunk alcohol . [ 8 ]
Whipple's triad is a collection of three signs (called Whipple's criteria) that suggests that a patient's symptoms result from hypoglycaemia that may indicate insulinoma.The essential conditions are symptoms of hypoglycaemia, low blood plasma glucose concentration, and relief of symptoms when plasma glucose concentration is increased.
Medications based on incretins are used in the treatment of type 2 diabetes mellitus as well as the management of obesity.. Most of the earliest incretin-targeting agents to be approved fell into the class of DPP-4 inhibitors; these inhibit DPP-4 and thus prevent the enzymatic degradation of GLP-1 and GIP.
The hypoglycemia of GSD I is termed "fasting", or "post-absorptive", usually about 4 hours after the complete digestion of a meal. This inability to maintain adequate blood glucose levels during fasting results from the combined impairment of both glycogenolysis and gluconeogenesis.
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