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The condition varies from a mild, self-limited rash (E. multiforme minor) [4] to a severe, life-threatening form known as erythema multiforme major (or erythema multiforme majus) that also involves mucous membranes. [5] Consensus classification: [6] Erythema multiforme minor—typical targets or raised, edematous papules distributed acrally
Erythema multiforme (EM) is generally considered a separate condition. [6] Treatment typically takes place in hospital such as in a burn unit or intensive care unit. [3] [7] Efforts include stopping the cause, pain medication, and antihistamines. [3] [4] Antibiotics, intravenous immunoglobulins, and corticosteroids may also be used.
Dogs with the condition have a poor life expectancy and are often euthanised after diagnosis. [17] Clinical signs include: facial erythema , crusting and scaling, [ 18 ] skin lesions, lameness, ulcers, and disfiguration: it progresses to joint pain and azoospermia in males and disruption of the oestrous cycle in females.
Stevens–Johnson syndrome (SJS) is a type of severe skin reaction. [1] Together with toxic epidermal necrolysis (TEN) and Stevens–Johnson/toxic epidermal necrolysis (SJS/TEN) overlap, they are considered febrile mucocutaneous drug reactions and probably part of the same spectrum of disease, with SJS being less severe.
In dermatology, erythema multiforme major is a form of rash with skin loss or epidermal detachment. The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation. [2] According to some sources, there are two conditions included on a spectrum of this same disease process: Stevens–Johnson syndrome (SJS)
Radiation-induced erythema multiforme may occur when phenytoin is given prophylactically to neurosurgical patients ... Dogs were also affected; in addition to ...
Target lesions are the typical lesions of erythema multiforme, in which a vesicle is surrounded by an often hemorrhagic maculopapule. Erythema multiforme is often self-limited, of acute onset, resolves in three to six weeks, and has a cyclical pattern. Its lesions are multiform (polymorphous) and include macules, papules, vesicles, and bullae.
Erythema (Ancient Greek: ἐρύθημα, from Greek erythros 'red') is redness of the skin or mucous membranes, caused by hyperemia (increased blood flow) in superficial capillaries. [1] It occurs with any skin injury, infection, or inflammation .