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Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen". [citation needed] Collagen IV exists in all metazoan phyla, to whom they served as an evolutionary stepping stone to multicellularity. [1] There are six human genes associated with it: [2] COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6
12826 Ensembl ENSG00000187498 ENSMUSG00000031502 UniProt P02462 P02463 RefSeq (mRNA) NM_001845 NM_001303110 NM_009931 RefSeq (protein) NP_001290039 NP_001836 NP_034061 Location (UCSC) Chr 13: 110.15 – 110.31 Mb Chr 8: 11.25 – 11.36 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on ...
Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene. [5] [6] [7] This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members ...