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The culprit can be both a prescription drug or an over-the-counter medication. Examples of common drugs causing drug eruptions are antibiotics and other antimicrobial drugs, sulfa drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), biopharmaceuticals, chemotherapy agents, anticonvulsants and psychotropic drugs.
Common side effects when taken by mouth include nausea and itchiness. [2] When applied to the skin, common side effects include redness and a burning sensation. [2] In pregnancy, use on the skin or in the vagina is believed to be safe. [2] There is no evidence of harm when used by mouth during pregnancy but this has been less well studied. [2]
It is available over-the-counter and is typically sold under such brand names as Equate or Unisom, among others; and it is used in nighttime cold medicines (e.g., NyQuil) and pain medications containing acetaminophen and/or codeine to help with sleep. The medication is delivered chemically by the salt doxylamine succinate and is taken by mouth.
The side effects of oral treatment are significant and people without an infection should not take these drugs. [36] Azoles are the group of antifungals which act on the cell membrane of fungi. They inhibit the enzyme 14-alpha-sterol demethylase, a microsomal CYP, which is required for the biosynthesis of ergosterol for the cytoplasmic membrane.
Side effects in humans may include poor coordination, abdominal pain, vomiting, headache, and allergic reactions. [4] While it may be used during pregnancy, it is not recommended for use during breastfeeding. [4] Praziquantel is in the anthelmintic class of medications. [3] It works partly by affecting the function of the worm's sucker. [3]
Metamizole is banned in several countries, available by prescription in others (sometimes with strong warnings, sometimes without), and available over the counter in yet others. [ 18 ] [ 46 ] [ 47 ] For example, approval was withdrawn in Sweden (1974), the US (1977), [ 48 ] and India (2013, ban lifted in 2014).