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[5] [64] Sedative antihistamines, such as diphenhydramine, may be useful in those who are unable to sleep due to eczema. [5] Second generation antihistamines have minimal evidence of benefit. [65] Of the second generation antihistamines studied, fexofenadine is the only one to show evidence of improvement in itching with minimal side effects. [65]
First-generation antihistamines can easily cross the blood-brain barrier into the central nervous system to reach the H-1 receptors within, often causing drowsiness. [7] Second-generation antihistamines selectively bind to the peripheral H-1 receptors outside the blood-brain barrier, therefore they are less likely to cause sedation.
Cetirizine is a second-generation antihistamine used to treat allergic rhinitis (hay fever), dermatitis, and urticaria (hives). [5] It is taken by mouth. [6] Effects generally begin within thirty minutes and last for about a day. [6]
What it looks like: Medically known as atopic dermatitis, eczema is an umbrella term for a range of skin conditions characterized by red, splotchy, dry, cracked, crusty, or flaky skin, that can ...
Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects. [11] [2] Diphenhydramine is also a potent anticholinergic. [12]
Pain can also be present. Dermatitis can occur anywhere on the skin, but is most common on the hands (22% of people), scattered across the body (18%), or on the face (17%). [5] The rash and other symptoms typically occur 24 to 48 hours after the exposure; in some cases, the rash may persist for weeks. [2]
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