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[55] [32] H. pylori-induced gastric cancer is the third highest cause of worldwide cancer mortality as of 2018. [56] Because of the usual lack of symptoms, when gastric cancer is finally diagnosed it is often fairly advanced. More than half of gastric cancer patients have lymph node metastasis when they are initially diagnosed. [57]
The World Health Organization's International Agency for Research on Cancer declares H. pylori a Group 1 carcinogen. [55] Parsonnet et al. describe an association between H. pylori and lymphomas of the gastrointestinal tract. These malignant ulcers can also be treated by eradicating Helicobacter. [56] 1997
In 1982, they performed the initial culture of H. pylori and developed their hypothesis on the bacterial cause of peptic ulcers and gastric cancer. [9] It has been claimed that the H. pylori theory was ridiculed by established scientists and doctors, who did not believe that any bacteria could live in the acidic environment of the stomach ...
The mechanism by which H. pylori causes cancer may involve chronic inflammation, or the direct action of some of its virulence factors, for example, CagA has been implicated in carcinogenesis. [44] As reviewed by Chang and Parsonnet, [45] chronic H. pylori infection in the human stomach is characterized by chronic inflammation. [45]
Helicobacter pylori colonizes the human stomach and duodenum. It is described as a Class 1 carcinogen. [2] In some cases it can cause stomach cancer [3] [4] and MALT lymphoma. [5] Animal models have demonstrated Koch's third and fourth postulates for the role of Helicobacter pylori in the causation of stomach cancer. [6]
Helicobacter heilmannii s.s. (H. heilmannii s.s.) is a species within the Helicobacter genus of Gram negative bacteria. [1] Helicobacter pylori (H. pylori) is by far the best known Helicobacter species primarily because humans infected with it may develop gastrointestinal tract diseases such as stomach inflammation, stomach ulcers, duodenal ulcers, stomach cancers of the non-lymphoma type, and ...
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