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Necrobiosis lipoidica is a rare, chronic skin condition predominantly associated with diabetes mellitus (known as necrobiosis lipoidica diabeticorum or NLD). [1] It can also occur in individuals with rheumatoid arthritis or without any underlying conditions ( idiopathic ). [ 2 ]
Necrobiosis lipoidica (NL) is chronic granulomatous disease of the skin. It involves shiny patches or plaques with a sclerotic center and inflammatory edge. It may appear on different parts of the body and specially, the front part of the legs. The atrophic scars remain after healing which can be inconvenient for patients.
Necrobiosis lipoidica; Limited joint mobility is observed in roughly 30% of people with diabetes with longstanding disease. [1] Scleredema; Waxy skin is observed in ...
Necrobiosis is the physiological death of a cell, and can be caused by conditions such as basophilia, erythema, or a tumor. It is identified both with [ 1 ] and without necrosis . Necrobiotic disorders are characterized by presence of necrobiotic granuloma on histopathology.
Diabetic cheiroarthropathy, also known as diabetic stiff hand syndrome or limited joint mobility syndrome, is a cutaneous condition characterized by waxy, thickened skin and limited joint mobility of the hands and fingers, leading to flexion contractures, a condition associated with diabetes mellitus [1]: 681 and it is observed in roughly 30% of diabetic patients with longstanding disease.
At the solar elastosis level, there is no necrobiosis, such as facial necrobiosis lipoidica, or mucinosis, such as GA or sarcoid-like granuloma in the dermis. [7] Because of the similarities in clinical manifestations, Actinic granuloma is easily confused with annular granuloma and sarcoidosis. In such cases, a histopathological examination is ...
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