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The clinical uses of MEG are in detecting and localizing pathological activity in patients with epilepsy, and in localizing eloquent cortex for surgical planning in patients with brain tumors or intractable epilepsy. The goal of epilepsy surgery is to remove the epileptogenic tissue while sparing healthy brain areas. [29]
The initial motivation for EEG-fMRI was in the field of research into epilepsy, and in particular the study of interictal epileptiform discharges (IED, or interictal spikes), and their generators, and of seizures. IED are unpredictable and sub-clinical events in patients with epilepsy that can only be observed using EEG (or MEG).
Some patients may have disorders such as compulsive lying, which makes certain studies impossible. [49] It is harder for those with clinical problems to stay still for long. Using head restraints or bite bars may injure epileptics who have a seizure inside the scanner; bite bars may also discomfort those with dental prostheses. [50]
Difference images calculated from ictal and interictal technetium-99m-HMPAO SPECT scans of epilepsy. Journal of Nuclear Medicine, 36:684-689. This is the first paper which describes the use of ictal-interictal difference imaging coregistered with MRI for epilepsy surgery localization.
[18] [19] Magnetoencephalography (MEG) research at Pico has improved the precision of brain mapping and subsequent surgery to remove parts of the brain responsible for some kinds of epilepsy. [20] Research on in vivo magnetic resonance spectroscopy focuses on brain metabolism [ 21 ] and on development of hyperpolarization agents to enhance ...
Researcher at the BIC have access to a 3.0 Tesla (3T) MRI scanner (Siemens), the first full-body 7.0 Tesla (7T) MRI scanner (Siemens) in Canada, a 275-channel CTF MEG system, electroencephalography (EEG), and transcranial magnetic stimulation (TMS), among others. [11]