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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum of the clitoris and of the penis as well as the retina. [5] It has also been recently discovered to play a vital role in the cardiovascular system.
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
All four of the oral medications listed above belong to a class of drugs called PDE5 inhibitors, which work by inhibiting the effects of the enzyme phosphodiesterase type 5 (PDE5).
What is Cialis (Tadalafil)? Like other ED medications, Cialis is a PDE5 inhibitor.It works by blocking the effects of PDE5, or cGMP-specific phosphodiesterase type 5 — an enzyme that’s ...
PDE5 stands for phosphodiesterase type 5, an enzyme that plays an important role in regulating blood flow to many parts of your body, including the soft tissues inside your privates.