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Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
The mammalian target of rapamycin (mTOR), [5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. [6] [7] [8] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein ...
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
Yoo, Young Ji; Hwang, Jae-yeon; Shin, Hea-luyung; Cui, Heqing; Lee, Jinwon; Yoon, Yeo Joon (26 November 2014). "Characterization of negative regulatory genes for the biosynthesis of rapamycin in Streptomyces rapamycinicus and its application for improved production". Journal of Industrial Microbiology & Biotechnology. 42 (1): 125–135.
Paradoxically, even though rapamycin is a federally approved immunosuppressant, its inhibition of mTORC1 results in better quantity and quality of functional memory T cells. mTORC1 inhibition with rapamycin improves the ability of naïve T cells to become precursor memory T cells during the expansion phase of T cell development . [78]
NHS England has been criticised for delays in deciding on a policy for the prescription of everolimus in the treatment of Tuberous Sclerosis. 20 doctors addressed a letter to the board in support of the charity Tuberous Sclerosis Association saying " around 32 patients with critical need, whose doctors believe everolimus treatment is their best or only option, have no hope of access to funding.
Food and agriculture nonprofits (FANOs) are an understudied player in food system sustainability and food waste management ([81]). FANOs play an essential role at every step of the food supply chain ([81]) including in creating or preventing food waste ). Food waste can be defined as edible food discarded by consumers.
A big part of waste management deals with municipal solid waste, which is created by industrial, commercial, and household activity. [4] Waste management practices are not the same across countries (developed and developing nations); regions (urban and rural areas), and residential and industrial sectors can all take different approaches. [5]