Search results
Results From The WOW.Com Content Network
Human tumors often display intratumoral heterogeneity for various biological features. Intratumoral heterogeneity can be due to the presence of multiple genetically distinct subclones within a single tumor (left).
Here, we discuss the main sources of intratumoral heterogeneity and its impact on the natural history of the disease, including sensitivity to treatment, as we delineate potential strategies to...
A study identifies 41 consensus gene expression meta-programs that are coordinately upregulated in subpopulations of malignant cells across tumour types, providing a comprehensive picture of ...
Intratumour heterogeneity (ITH) is a hallmark of cancer that drives tumour evolution and disease progression. Technological and computational advances have enabled us to assess ITH at...
Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin (mTOR) kinase, correlating with S6 and 4EBP phosphorylation in vivo and...
Intratumoral heterogeneity arises through complex genetic, epigenetic, and protein modifications that drive phenotypic selection in response to environmental pressures. Functionally, heterogeneity provides tumors with significant adaptability.
However, our understanding of mechanisms that regulate intratumoral heterogeneity and our ability to modulate it has been lagging behind. Recent data demonstrate that epigenetic regulators, including histone demethylases, may control the cell-to-cell variability of transcriptomes and chromatin profiles and they may modulate therapeutic ...
High intratumor heterogeneity (ITH) is associated with poor outcome in many human cancer types, and it may include heterogeneity for genetic, epigenetic, and phenotypic features. The assessment of ITH in clinical samples using deep-resolution single-cell multiomics approaches facilitates the understanding of its role in tumor evolution and ...
Intratumor heterogeneity represents integration of inputs from genetic, phenotypic, and microenvironmental heterogeneity, in turn increasing the odds of both pre-existence of tolerant and resistant subpopulations, and the ability to evolve new adaptations.
Intratumoral Cellular Genetic Heterogeneity and Drug-Tolerant Persisters. Human tumors often display intratumoral heterogeneity for various biological features. Intratumoral heterogeneity can be due to the presence of multiple genetically distinct subclones within a single tumor (left).