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A Brief History of Sickle Cell Disease. “Peculiar elongated and sickle-shaped” is how sickle cells were first described in 1904 by intern Ernest Edward Irons when examining the blood of Walter Clement Noel, a 20-year-old first-year dental student from a wealthy Black family in Grenada.
Abstract. The term sickle cell disease embraces a group of genetic conditions in which pathology results from the inheritance of the sickle cell gene either homozygously or as a double heterozygote with another interacting gene.
“Peculiar elongated and sickle-shaped” is how sickle cells were first described in 1904 by intern Ernest Edward Irons when examining the blood of Walter Clement Noel, a 20-year-old first-year dental student from a wealthy Black family in Grenada.
Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited. [2] The most common type is known as sickle cell anemia. [2] It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2]
Sickle cells were first found in the US in people of African origin, but they are also common in people from the eastern Mediterranean (particularly Greece), the Middle East and parts of Asia.
The discovery of hemoglobin ‘S’ by Linus Pauling and Colleague in 1949 was the first demonstration that the production of an abnormal protein could be the cause of a genetic disorder 1. So was born the notion of molecular basis of the disease and sickle cell disease (SCD) was the first one to be described. In 1956, Vernon Ingram identified ...
In the western literature, the first description of sickle cell disease was by a Chicago physician, James B. Herrick, who noted in 1910 that a patient of his from the West Indies had an anemia characterized by unusual red cells that were "sickle shaped.".
Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels.
The first case of sickle cell disease (SCD) in the United States was described in 1904 when Walter Clement Noel, a 20-year-old dental student from Grenada, sought care for anemia at Chicago Presbyterian Hospital where he met Dr. James B. Herrick (1861-1954), a cardiologist and professor of medicine. Noel experienced recurrent episodes of ...
Sickle cell disease is caused by an inherited genetic mutation that affects an individual’s hemoglobin, a protein within the red blood cells. When people inherit this form of hemoglobin, it impacts how red blood cells form in the body.