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Thus, asthma is a chronic inflammatory disorder of the airways. Asthma is divided into two subgroups: atopic (extrinsic) and non-atopic (intrinsic). The atopic subgroup is closely associated with family history of the disease, whereas the non-atopic subgroup has its onset in adulthood and it is not caused by inheritance.
Asthma phenotyping and endotyping has emerged as a novel approach to asthma classification inspired by precision medicine which separates the clinical presentations of asthma, or asthma phenotypes, from their underlying causes, or asthma endotypes. The best-supported endotypic distinction is the type 2-high/type 2-low distinction.
The Centers for Disease Control and Prevention estimate that 1 in 11 children and 1 in 12 adults have asthma in the United States of America. [1] According to the World Health Organization, asthma affects 235 million people worldwide. [2] There are two major categories of asthma: allergic and non-allergic.
The cause for acute severe asthma attacks is still unknown and experts are also unsure of why it developed and why it does not respond to typical asthma treatments. [7] [medical citation needed] Not seeing a doctor regularly, therefore asthma is not under good control; Coming in contact with asthma triggers; Allergies or severe allergic reactions
Asthma is a common condition and affects over 300 million people around the world. [3] Asthma causes recurring episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning. [4] Exercise-induced asthma is common in asthmatics, especially after participation in outdoor activities in cold weather.
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Respiratory disease is a common and significant cause of illness and death around the world. In the US, approximately one billion common colds occur each year. [ 29 ] A study found that in 2010, there were approximately 6.8 million emergency department visits for respiratory disorders in the U.S. for patients under the age of 18. [ 30 ]
Cadherin related family member 3 (CDHR3), also known as CDH28 or its abbreviation CDHR3, is a protein that in humans is encoded by the CDHR3 gene. [5] The protein is predominately expressed in respiratory epithelium [6] and the first notion of its clinical implications was from the discovery that genetic variation of CDHR3 is strongly associated to early severe asthma exacerbations in children ...