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Because of its long elimination half-life, dutasteride requires 5 to 6 months to reach steady-state concentrations. [59] It also remains in the body for a long time after discontinuation and can be detected up to 4 to 6 months. [1] [2] In contrast to dutasteride, finasteride has a short terminal half-life of only 5 to 8 hours.
Antiandrogens. Finasteride is used to treat male pattern hair loss. [25] Treatment provides about 30% improvement in hair loss after six months of treatment, and effectiveness only persists as long as the drug is taken. [20] There is no good evidence for its use in women. [14] It may cause gynecomastia, erectile dysfunction and depression.
Dermatology, plastic surgery. Pattern hair loss (also known as androgenetic alopecia (AGA) [1]) is a hair loss condition that primarily affects the top and front of the scalp. [2][3] In male-pattern hair loss (MPHL), the hair loss typically presents itself as either a receding front hairline, loss of hair on the crown and vertex of the scalp ...
One study from 2006 compared the effects of finasteride and dutasteride on 416 men between 21 to 45 years old who received either dutasteride, finasteride or a placebo treatment.
Finasteride (brand names Proscar, Propecia) inhibits the function of two of the isoenzymes (types 2 and 3) of 5α-reductase. [6][7] It decreases circulating DHT levels by up to about 70%. [8] Dutasteride (brand name Avodart) inhibits all three 5α-reductase isoenzymes and can decrease DHT levels by 95%. [9][10] It can also reduce DHT levels in ...
Finasteride has been found to be effective in the treatment of hirsutism (excessive facial and/or body hair growth) in women. In a study of 89 women with hyperandrogenism due to persistent adrenarche syndrome, finasteride produced a 93% reduction in facial hirsutism and a 73% reduction bodily hirsutism after 2 years of treatment. Other studies ...
The medical uses of bicalutamide, a nonsteroidal antiandrogen (NSAA), include the treatment of androgen-dependent conditions and hormone therapy to block the effects of androgens. Indications for bicalutamide include the treatment of prostate cancer in men, skin and hair conditions such as acne, seborrhea, hirsutism, and pattern hair loss in ...
Oophorectomy has serious long-term consequences stemming mostly from the hormonal effects of the surgery and extending well beyond menopause. The reported risks and adverse effects include premature death, [ 21 ] [ 22 ] cardiovascular disease, cognitive impairment or dementia, [ 23 ] parkinsonism , [ 24 ] osteoporosis and bone fractures ...