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2. Tricyclic antidepressant - Wikipedia

   en.wikipedia.org/wiki/Tricyclic_antidepressant

   Side effects may also be less troublesome if treatment is initiated with low doses and then gradually increased, although this may also delay the beneficial effects. TCAs can behave like class 1A antiarrhythmics , as such, they can theoretically terminate ventricular fibrillation, decrease cardiac contractility and increase collateral blood ...

3. Serotonin–norepinephrine–dopamine reuptake inhibitor

   en.wikipedia.org/wiki/Serotonin–norepinephrine...

   The TCAs such as imipramine and amitriptyline typically prevent the reuptake of serotonin or norepinephine. It is the histaminiergic (H 1), muscarinic acetylcholinergic (M 1), and alpha adrenergic (α 1) blockade that is responsible for the side-effects of TCAs. These include somnolence and lethargy, anticholinergic side-effects, and hypotension.

4. Trimipramine - Wikipedia

   en.wikipedia.org/wiki/Trimipramine

   The side effects of trimipramine have been said to be similar to those of other tertiary amine TCAs, with a preponderance of anticholinergic and sedative effects. [9] However, trimipramine has also been said to be associated with a different side effect profile compared to other TCAs and in general with fewer side effects, chiefly due to its lack of norepinephrine reuptake inhibition and ...

5. Tetracyclic antidepressant - Wikipedia

   en.wikipedia.org/wiki/Tetracyclic_antidepressant

   TeCAs block the histamine H 1 receptor similarly to the TCAs, but tend to be even stronger antihistamines than TCAs [citation needed]. On the other hand, in contrast to almost all TCAs, TeCAs have only low affinity for the muscarinic acetylcholine receptors, and for this reason, are associated with few or no anticholinergic side effects ...

6. Breakthrough antidepressants with fewer side effects could ...

   www.aol.com/finance/breakthrough-antidepressants...

   They have largely been replaced by drugs with fewer side effects. SSRIs (selective serotonin reuptake inhibitors), which debuted in the 1980s, work on serotonin.

7. Management of prostate cancer - Wikipedia

   en.wikipedia.org/wiki/Management_of_prostate_cancer

   For men over 64 with prostate cancer limited to the pelvis, using fewer, larger doses of radiation (hypofractionation) results in similar overall survival rates. [28] The risk of dying from prostate cancer or having acute bladder side effects may be similar to that of longer radiation treatment. [28]