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Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
The symptoms of Cushing's disease are similar to those seen in other causes of Cushing's syndrome. [5] Patients with Cushing's disease usually present with one or more signs and symptoms secondary to the presence of excess cortisol or ACTH. [6] Although uncommon, some patients with Cushing's disease have large pituitary tumors (macroadenomas).
Trilostane was withdrawn from human use in the United States market in April 1994. [22] [23] [10] It continued to be available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing's disease and breast cancer in humans, but was eventually discontinued in this country as well. [10] [24] [25] [26]
Cushing syndrome is a condition that occurs when your body makes too much of the hormone cortisol over a long period, according to the National Institute of Diabetes and Digestive and Kidney ...
However, careful monitoring is essential during treatment, as these drugs can potentially cause side effects and, in some cases, lead to adrenal insufficiency. [7] While antiglucocorticoid therapy has shown promise in managing Cushing's syndrome, it is generally considered an adjunctive treatment to surgery, which remains the definitive cure ...
However, side effects for these medications could include tiredness, upset stomach, vomiting, headaches, muscle aches, high blood pressure, low potassium and swelling, per Mayo Clinic. More ...
About 70% of people with Cushing syndrome are women or people assigned female at birth, according to the Cleveland Clinic. People between 25 and 50 are most likely to be affected by the condition.
Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been used in the treatment of seizures, Cushing's syndrome, breast cancer, and prostate cancer, among other indications.
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