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In recognition of his contribution, the depth of invasion of melanoma is referred to by the eponym Breslow's depth. Subsequent studies confirmed and refined the role of depth of invasion in the prognosis of malignant melanoma. [2] [3] Currently, Breslow's depth is included in the AJCC staging guidelines for melanoma as a major prognostic factor.
The biopsy should include the epidermal, dermal, and subcutaneous layers of the skin. This enables the histopathologist to determine the thickness of the melanoma by microscopic examination. This is described by Breslow's thickness (measured in millimeters). However, for large lesions, such as suspected lentigo maligna, or for lesions in ...
The prognosis of acral lentiginous melanoma is based on multiple factors including sex, age, race, Breslow depth, staging, and sentinel lymph node positivity. [7] Out of these factors, it is believed that sentinel lymph node positivity provides the strongest prediction of cancer recurrence and death.
Any diagnosis of melanoma is cancer even if the term ‘malignant’ is not used before it.
Level 1: Melanoma confined to the epidermis (melanoma in situ) ... A resource on Clark's levels and Breslow's depth. Original article from Breslow. Cancer res, 1969.
Melanoma: TNM used. Also of importance are the "Clark level" and "Breslow depth" which refer to the microscopic depth of tumor invasion ("Microstaging"). [13] Prostate cancer: TNM almost universally used. [14] Testicular cancer: uses TNM along with a measure of blood serum markers (TNMS). Non-melanoma skin cancer: uses TNM. Bladder cancer: uses ...